828cloud

Data, Info and News of Life and Economy

Daily Archives: January 8, 2022

Charts: U.S. Non Farm Payrolls Disappointed in December 2021

199K jobs added, well below market forecast of 400K

Source: Trading Economics

Charts: U.S. Total Consumer Credit Exploded by $40 billion, the Highest on Record

Source: Bloomberg and The Federal Reserve

In Pictures: 1967 Shelby Mustang GT500 4-Speed

Source : Bring A Trailer

The World’s First Octopus Farm – Should It Go Ahead?

Claire Marshall wrote . . . . . . . . .

News that the world’s first commercial octopus farm is closer to becoming reality has been met with dismay by scientists and conservationists. They argue such intelligent “sentient” creatures – considered able to feel pain and emotions – should never be commercially reared for food.

Playing with a Giant Pacific Octopus is part of Stacey Tonkin’s job. When she lifts the lid on the tank to feed the creature known as DJ – short for Davy Jones – he often scoots out from his cave to see her and stick his arms on the glass. That’s if he’s in a good mood. Octopuses live to be about four – so, at one year old, she says that he’s the equivalent of a teenager.

“He definitely exhibits what you’d expect a teenager to be like – some days he’s really grumpy and sleeps all day. Then other days he’s really playful and active and wants to charge around his tank and show off.”

The keepers feed the octopus with mussels and prawns and bits of fish and crab. Sometimes they put the food in a dog toy for him to tease out with his tentacles, so he can practise his hunting skills.

She says his colour changes with his moods. “When he’s an orangey brown, it’s more like an active or playful kind of feeling. Speckly is more curious and interested. So he’ll be swimming around orange and brown, then he’ll come over and sit beside you and go all speckly and just look at you, which is quite amazing.

Stacey says the octopus shows his intelligence through his eyes. “When you look at him, and he looks at you, you can sense there’s something there.”

The level of awareness that Stacey witnesses first-hand is to be recognised in UK law through an amendment to the Animal Welfare (Sentience) Bill.

The change has come after a team of experts sifted through more than 300 scientific studies and concluded that octopuses were “sentient beings” and there was “strong scientific evidence” that they could experience pleasure, excitement and joy – but also pain, distress and harm.

The authors said they were “convinced that high-welfare octopus farming was impossible” and the government “could consider a ban on imported farmed octopus” in future.

But octopus tentacles sizzle in pans, coil on plates and float in soups around the world – from Asia to the Mediterranean, and increasingly the USA. In South Korea, the creatures are sometimes eaten alive. The number of octopuses in the wild are decreasing and prices are going up. An estimated 350,000 tonnes are caught each year – more than 10 times the number caught in 1950.

Against that background, the race to discover the secret to breeding the octopus in captivity has been going on for decades. It’s difficult – the larvae only eat live food and need a carefully controlled environment.

The Spanish multinational, Nueva Pescanova (NP) appears to have beaten companies in Mexico, Japan and Australia, to win the race. It has announced that it will start marketing farmed octopus next summer, to sell it in 2023.

The company built on research done by the Spanish Oceanographic Institute (Instituto Español de Oceanografía), looking at the breeding habits of the Common Octopus – Octopus vulgaris. NP’s commercial farm will be based inland, close to the port of Las Palmas in the Canary Islands according to PortSEurope.

It’s reported the farm will produce 3,000 tonnes of octopus per year. The company has been quoted as saying it will help to stop so many octopus being taken from the wild.

Nueva Pescanova has refused to reveal any details of what conditions the octopuses will be kept in, despite numerous approaches by the BBC. The size of the tanks, the food they will eat and how they will be killed are all secret.

The plans have been denounced by an international group of researchers as “ethically and ecologically unjustified”. The campaign group Compassion in World Farming (CIWF) has written to the governments of several countries – including Spain – urging them to ban it.

Dr Elena Lara, CIWF’s research manager, is angry. “These animals are amazing animals. They are solitary, and very smart. So to put them in barren tanks with no cognitive stimulation, it’s wrong for them.”

She says anyone who has watched the 2021 Oscar-winning documentary – My Octopus Teacher – will appreciate that.

Octopuses have large, complex brains. Their intelligence has been proven in numerous scientific experiments. They’ve been observed using coconut and sea shells to hide and defend themselves and have shown they can learn set tasks quickly. They’ve also managed to escape from aquariums and steal from traps set by people fishing.

What’s more, they have no skeletons to protect them and are highly territorial. So they could be easily damaged in captivity and – if there was more than one octopus in a tank – experts say they could start to eat each other.

If the octopus farm does open in Spain, it seems the creatures bred there would receive little protection under European law. Octopuses – and other invertebrate cephalopods – are considered as sentient beings, but EU law covering farm animal welfare is only applied to vertebrates – creatures that have backbones. Also, according to CIWF, there is currently no scientifically validated method for their humane slaughter.

Humans and octopuses had a common ancestor 560 million years ago, and evolutionary biologist Dr Jakob Vinther, from the University of Bristol, also has concerns.

“We have an example of an organism that has evolved to have an intelligence that is extremely comparable to ours.” Their problem-solving abilities, playfulness and curiosity are very similar to those of humans, says Dr Vinther – and yet they’re otherworldly.

“This is potentially how it would look if we were ever going to meet an intelligent alien from a different planet.”

Nueva Pescanova says on its website that it is “firmly committed to aquaculture [farming seafood] as a method to reduce pressure on fishing grounds and ensure sustainable, safe, healthy, and controlled resources, complementing fishing”.

But CIWF’s Dr Lara argues that NP’s actions are purely commercial and the company’s environmental argument is illogical. “It doesn’t mean that fishermen will stop fishing [octopuses].”

She argues that farming octopuses could add to the growing pressure on wild fish stocks. Octopuses are carnivores and need to eat two-to-three times their own weight in food to live. Currently around one-third of the fish caught around the planet is turned into feed for other animals – and roughly half of that amount goes into aquaculture. So farmed octopus could be fed on fish products from stocks already overfished.

Dr Lara is concerned consumers who want to do the right thing may think eating farmed octopus is better than octopus caught in the wild. “It’s not more ethical at all – the animal is going to be suffering its entire life,” she says. And a 2019 report – led by associate professor of environmental studies at NYU, Jennifer Jacquet – argues that banning octopus farming wouldn’t leave humans without enough to eat. It will mean “only that affluent consumers will pay more for increasingly scarce, wild octopus,” it states.

The whole debate is fraught with cultural complexities.

Factory farming on land has evolved differently around the world. Pigs, for example, have been shown to be intelligent – so what’s the difference between a factory-farmed pig producing a bacon sandwich, and a factory-farmed octopus being put in the common Spanish dish Pulpo a la Gallega?

The conservationists argue the sentience of many farmed animals wasn’t known when the intensive systems were set up, and the mistakes of the past shouldn’t be repeated.

Because pigs have been domesticated for many years, we have enough knowledge about their needs and know how to improve their lives, says Dr Lara. “The problem with octopus is that they are completely wild, so we don’t know exactly what they need, or how we can provide a better life for them.”

Given all we know about the intelligence of octopuses, and the fact they are not essential for food security, should an intelligent, complex creature start to be mass-produced for food?

“They are extremely complex beings,” says Dr Vinther. “I think as humans we need to respect that if we want to farm them or eat them.”


Source : BBC

Antibody-dependent Enhancement (ADE) and Vaccines

Immune responses to pathogens involve many cells and proteins of the immune system. Early during an infection, these responses are non-specific, meaning that although they are directed at the pathogen, they are not specific to it. This is called innate immunity. Within a few days, adaptive immunity takes over; this immunity is specific to the invading pathogen. Adaptive immune responses include antibodies. A major goal of antibodies is to bind to the pathogen and prevent it from infecting, or entering, a cell. Antibodies that prevent entry into cells are called neutralizing antibodies. Many vaccines work by inducing neutralizing antibodies. However, not all antibody responses are created equal. Sometimes antibodies do not prevent cell entry and, on rare occasions, they may actually increase the ability of a virus to enter cells and cause a worsening of disease through a mechanism called antibody-dependent enhancement (ADE).

What is ADE?

ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. Instead, these antibodies act as a “Trojan horse,” allowing the pathogen to get into cells and exacerbate the immune response.

Importantly, when a vaccinated person subsequently gets infected, this is not automatically evidence of ADE. Specifically, if a vaccinated person gets infected with the pathogen against which the vaccine protects, three different scenarios can occur:

Mild illness – In this scenario, the person may experience some symptoms, but they are more of an inconvenience and last only a few days (typically about 1-3 days). For many respiratory and gastrointestinal infections (e.g., influenza, COVID-19, and rotavirus), this is common. These mild symptoms are evidence that the vaccine worked.

“Breakthrough illness” – Traditionally, this term has been reserved for vaccinated people who get more severely ill, requiring hospitalization or experiencing untoward outcomes, such as disease complications (e.g., pneumonia) or death. In this case, the vaccine may not have worked at all or it did not induce high enough levels of immunity to effectively stop an infection.

ADE – In this scenario, the antibodies that the vaccine generated actually help the virus infect greater numbers of cells than it would have on its own. In this situation, the antibodies bind to the virus and help it more easily get into cells than it would on its own. The result is often more severe illness than if the person had been unvaccinated. ADE can occur after disease and has on occasion been identified following vaccination, as described below. Any vaccine that has been found to cause ADE has stopped being used or, more recently as described below for dengue vaccine, been recommended only for those who will not be affected by ADE. Evidence of ADE has not emerged for COVID-19 vaccines even though concerns have been raised.

Is ADE caused by a disease?

Most diseases do not cause ADE, but one of the best studied examples of a pathogen that can cause ADE is dengue virus. Dengue virus is one of the most common infections in the world, infecting hundreds of millions and killing tens of thousands of people each year. Unlike viruses like measles or mumps that only have one type, dengue virus has four different forms, called “serotypes.” These serotypes are very similar, but slight differences among them set the stage for ADE. If a person is infected by one serotype of dengue virus, they typically have mild disease and generate a protective immune response, including neutralizing antibodies, against that serotype. But, if that person is infected with a second serotype of dengue virus, the neutralizing antibodies generated from the first infection may bind to the virus and actually increase the virus’s ability to enter cells, resulting in ADE and causing a severe form of the disease, called dengue hemorrhagic fever.

Is ADE caused by vaccines?

On a few occasions ADE has resulted from vaccination:

Respiratory syncytial virus (RSV) — RSV is a virus that commonly causes pneumonia in children. A vaccine was made by growing RSV, purifying it, and inactivating it with the chemical formaldehyde. In clinical trials, children who were given the vaccine were more likely to develop or die from pneumonia after infection with RSV. As a result of this finding, the vaccine trials stopped, and the vaccine was never submitted for approval or released to the public.

Measles — An early version of measles vaccine was made by inactivating measles virus using formaldehyde. Children who were vaccinated and later became infected with measles in the community developed high fevers, unusual rash, and an atypical form of pneumonia. Upon seeing these results, the vaccine was withdrawn from use, and those who received this version of the vaccine were recommended to be vaccinated again using the live, weakened measles vaccine, which does not cause ADE and is still in use today.

Both the RSV and measles vaccines that caused ADE were tested in the 1960s. Since then, other vaccines have successfully been created by purifying and chemically inactivating the virus with formaldehyde, such as hepatitis A, rabies, and inactivated polio vaccines. These more recent vaccines do not cause ADE.

A more recent example of ADE following vaccination comes from dengue virus:

Dengue virus — In 2016, a dengue virus vaccine was designed to protect against all four serotypes of the virus. The hope was that by inducing immune responses to all four serotypes at once, the vaccine could circumvent the issues related to ADE following disease with dengue virus. The vaccine was given to 800,000 children in the Philippines. Fourteen vaccinated children died after encountering dengue virus in the community. It is hypothesized that the children developed antibody responses that were not capable of neutralizing the natural virus circulating in the community. As such, the vaccine was recommended only for children greater than 9 years of age who had already been exposed to the virus.

Other viral vaccines that target multiple types of a virus have been safely used, including vaccines against polio (3 types), rotavirus (5 types), and human papillomavirus (9 types).

Should I be concerned that my child will develop ADE after receiving a vaccination?

Today’s routinely recommended vaccines do not cause ADE. If they did, like those described above, they would be removed from use. Phase III clinical trials are designed to uncover frequent or severe side effects before a vaccine is approved for use. Find out more about how vaccines are developed and approved for use.

Can the new COVID-19 vaccines cause ADE?

Neither COVID-19 disease nor the new COVID-19 vaccines have shown evidence of causing ADE. People infected with SARS-CoV-2, the virus that causes COVID-19, have not been likely to develop ADE upon repeat exposure. This is true of other coronaviruses as well. Likewise, studies of vaccines in the laboratory with animals or in the clinical trials in people have not found evidence of ADE.

Following the experience with dengue vaccine, early during the COVID-19 pandemic, concerns about ADE were top of mind. During this time, a few scientists tried to predict whether ADE would occur by evaluating genes for similarities and differences. While this was a useful approach at a time when we did not have much information about what might happen in people, we have since accumulated several lines of clinical evidence that confirm ADE is not an issue for COVID-19 or the vaccines:

People who are infected with SARS-CoV-2, or its variants, do not become more susceptible to ADE.

Many vaccinated people have been exposed to the virus, and its variants, and most of them have developed no disease or mild symptoms. A very small number have experienced more severe disease (“breakthrough infection”), and these individuals have not shown evidence of ADE.

Unfortunately, some people continue to spread misinformation suggesting that ADE is an ongoing concern for COVID-19 vaccines; however, scientists and clinicians are continuing to monitor COVID-19 infections and, to date, no evidence to validate this concern has emerged.


Source : The Children’s Hospital of Philadelphia

This Man Is Turning Cities into Giant Sponges to Save Lives

Joe Myers wrote . . . . . . . . .

The idea of a sponge city is simple – rather than using concrete to channel away rainwater, you work with nature to absorb, clean and use the water.

“Floods are not enemies,” explains Professor Kongjian Yu. “We can make friends with floods. We can make friends with water.”

What we have done is totally wrong, he says. He returned to China after studying landscape architecture at Harvard University in the US, determined to tackle one of the biggest problems facing cities.

His solution was to work with nature rather than against it.

Natural flow

Eco-friendly terraces allow land and water to meet, explains Kongjian, or “the Sponge Cities Architect” as he’s known.

During the dry season, the terrace is a park for residents to enjoy. But during the rainy season it can flood, protecting the city without the need for grey infrastructure like flood walls or dykes.

Not only does this safeguard the city by working with nature, but the water is clean, vegetation can grow and a habitat is created for wildlife.

It’s not just wetlands and restored riverbanks, though. Sponge cities also include green walls and roofs, permeable pavements and green buildings.

All from one city

And it all began in just one Chinese city, 20 years ago.

Today, 250 places in the country are working with Kongjian and his team, as well as urban areas everywhere from the US and Russia to Indonesia.

It’s an inherently global answer to a problem that afflicts a variety of places, he believes. “The ecological-based or nature-based solution can be a solution global-wise.”


Source : World Economic Forum


Watch video at You Tube (4:27 minutes) . . . .

The BNT162b2 mRNA Vaccine Against SARS-CoV-2 Reprograms both Adaptive and Innate Immune Responses

Jessica Rose wrote . . . . . . . . .

A brand new medRxiv pre-print study entitled: “The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses” has graced our world. This paper is so important and it provides evidence to support what many prominent immunologists and vaccinologists have been saying for a long time, including myself. These COVID-19 mRNA injectable products are causing, yes, causing, immune system dysregulation – and not just in the context of the adaptive system, but in the context of the innate system. Not only that, but these findings provide very good reasons as to why we are seeing resurgences of latent viral infections and other adverse events reported in VAERS (and other adverse event reporting systems) and perhaps more importantly, why we should under no circumstances inject this crap into our children. Children are fine in the context of COVID-19 (for the 80 millionth time – this well documented) and this is due to their extraordinary innate immune response systems.

Let’s rip into some background in immunology, shall we?

The Figure below shows many of the different cell types involved in the adaptive and the innate immune system branches. Most of you probably know about T cells and B cells. I would bet that many more of you have not heard of my personal favorite killer, the Natural Killer (NK) cell. They kill infected cells and are of utmost importance to a healthy and functioning immune system. The cell types involved in the innate immune response system emit special molecules in response to invaders. These special molecules primarily comprise defensins, collectins, c-reactive proteins, lipopolysaccharide (endotoxin) binding proteins and complement factors. These responses are non-specific and target invading pathogens and even cancer cells.

In a nutshell, in this article, what they found was that the BNT162b2 (Pfizer/BioNTech) injectable products are modulating the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli whereby the response of innate immune cells to TLR4 and TLR7/8 ligands was weaker after BNT162b2 injection, while fungi-induced cytokine responses were stronger.

In conclusion, the mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development and use of this new class of vaccines.

Yes. It should be. And it should have been.

So what is inside the nutshell? Let’s back it up a bit, shall we? What are acquired/adaptive immune responses and more importantly, what are innate immune responses? I did say we were going to rip into immunology. Our immune system’s first line of defense is called the innate immune system. It comprises the skin (chock full of epidermal dendritic cells or Langerhans cells), mucous and mucosal epithelium, immune cells such as natural killer cells, basophils, dendritic cells, mast cells and macrophages and many molecular mediators such as cytokines, interleukins, c-reactive proteins and complement factors. The complement system is an immutable system vital to proper functioning of antibodies and phagocytic cells (cells that eat stuff), clearance of invaders and damaged cells, inflammatory response promotion and membrane attack complex (MAC) formation. Membrane attack complex. Cool name for a band.

The mucus layer covering the mucosal epithelium acts as a first physical and biochemical barrier. An additional layer of physical protection against microorganisms is provided by a tightly interlaced cell-to-cell network of epithelial cells and intraepithelial lymphocytes. Various antimicrobial peptides produced by the epithelium and secreted into the mucosal lumen can directly kill the invading pathogenic bacteria.

Every single ‘invader’ such as bacteria or viruses have molecules on their surfaces known as Pathogen-Associated Molecular Patterns (PAMPs) that are detectable by cognate molecules on immune cell surfaces call Pattern Recognition Receptors (PRRs). One type of PRR are Toll-like Receptors (TLRs). These TLRs come in many types and bind to specific types of molecules. TLR-7, for example, binds single-stranded RNA (ssRNA). Hmm. Where have I seen that before? Oh right! SARS-nCoV-2 is an ssRNA virus. Interesting. There are also cell receptors called RIG-I-like receptors (RLRs) that sense viral RNA.

If a PAMP is detected by a PRR, an intracellular signalling cascade commences which results in the production of such inflammatory mediators as Nitric Oxide, histamine, TNF-alpha, IL-1 (protoypic inflammatory cytokine) and others as part of a pro-inflammatory reaction to quell invaders. Perhaps of primary note is that via TLR signalling – a prolific PRR type – Nuclear Factor kappa B (NF-kB) activation ensues. What is NF-kB?

NF-kB3 plays a key role in regulating the immune response to infection. Incorrect regulation of NF-kB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

In the presence of danger, the immune system responds via these fantastic on/off switches and mechanisms, to eliminate said dangers. This is the natural way of things and it is a constant ebb and flow of immune system regulatory magic.

Let’s assume the role of the coronavirus and see what our life would be like in the case of say, a child. You should know, once again, that children have very strong innate immune systems. The links attached refer to excellent works by Dr. Robert Malone and Dr. Francis Christian on this subject. So I’m a coronavirus and some arshole just sneezed me all over the face of a child standing next to me. The person who sneezed is one of those people who wears a mask incessantly on their chin and then sneezes all over everyone whilst symptomatic. So the child has me (Dr. Coronavirus or Dr. CV, for short) all over it’s face. And just so you know, there are many of me. So I find my way in a misty droplet into the sweet nasal cavity of this child where I encounter lots of mucousy membranes and sheets of epithelial cells. Lots of mucous. Mucosaliscious. I imagine it would be like running through a tunnel full of spider webs like Frodo Baggins did when he was trying to escape ‘she who needs to feed’ in order to get to the Mordor volcano to destroy the ring of power. So it’s kind of hard to get through. The nose. Sort of.

Ok, so most of me gets stuck in the booger path in the child’s nose. But nasal epithelial cells are chock full of ACE-2 receptors. I can bind them and thus can easily get inside the nice and warm cozy cells. There are also CD147 receptors here! So, a few of me manage to get ‘past’ this mucousy hurdle and bind to yummy epithelial cells via ACE-2 and CD147 receptors, which to me, are like red and yellow-colored lollipops of delight leading me into the place where I can call home and settle down and reproduce. But wait, before we get into that, since I am lurking around looking for receptors to bind, I am also encountering a lot of cells. These cells start telling me that they need to see my green pass if I want to keep lurking. No wait, no not my green pass, my PAMPs, so that they can find out how dangerous I am. I am new to this neck of the woods so they’re more than a little curious about my lurking. So they probe me with their PRR/TLR tools. Oh man! This is not pleasant at all! Being frisked by dendritic cells is like being manhandled by an octopus on a mission. So even though I have no idea, the by-product of their frisk is the inevitable launch of an army of things hell-bent on removing me from this kid. All of a sudden I’m surrounded by tenticular cells and they’re throwing TNF-alpha and IL-1 molotov cocktails at me! And it’s starting to get really hot in here and I’m like, man, this is not a hospitable environment. What did I do to deserve this? I’m just an innocent virus ultimately looking for a place to… breed.

Luckily, I have made a home in some cells. I am bound to others about to gain entry. But, the immune defenses don’t stop on the outside of cells; they continue on the inside. I thought I had found a nice warm and cuddly cell to settle down in and reproduce in. I have to think again! All of a sudden the PH is like, way too high! This feels awful! They’re trying to kill me, man! And eventually, they destroy me before I can get out. One of them sicked this crazy MAC on me and it poked holes in my home cell that I had managed to get into. They also used all sorts of internal and external armaments to make sure they cleared me out. And they did!

How do I know that? Because I am speaking from virus heaven.

So that’s the imaginary journey of the SARS-nCoV-2 virus and the potent response of a child’s innate immune system to my presence. Not enough cells get infected fast enough for an infection to ensue. The kid never gets to disease state and in most cases, symptoms are excessively mild or non-existent.

Alas, not enough of me were able to ‘infect’ enough cells to result in enough of me being produced to result in a ‘symptomatic infection’ party party. Innate immune system: 1. Coronavirus me: 0.

But what if I am reincarnated as mRNAs’ssss. And let’s go really sci-fi and imagine I am reincarnated as mRNAssss’s wrapped in a Lipid Nano Particle (LNP) bubble. And what if, I happened to be injected into someone’s arm muscle. What lives I am having! So what would be my fate? Well, surely, since I am injected intramuscularly with a pretty heavy guage needle (22–25-gauge 5/8 inch (16 mm)), I get inserted pretty deep and in copious amounts into muscle tissue. I witnessed many a muscle cell screaming in pain! I can’t really see anything yet because of this fat bubble I am in. But all of a sudden I feel us moving! So fast! The injector didn’t aspirate to check if I was being injected into the muscle as planned! It’s like riding the rapids of the cardiovascular system! Or something. Then suddenly we stop. There’s some kind of blurry kidney-shaped thing outside. It seems like the LNP has slimed its way into a cell. And I think we were just dumped out of the LNP into this cell. Well, ok. This is great news! Since we have been reincarnated into mRNAs, we can simply find ribosomes and start translating ourselves into the butterfly proteins we’ve always wanted to be! And there will be so much of us! Butterlies a swarmin’ in the body of a person! We have to act fast though, lest we be… degraded, however. I guess this is why we were wrapped in a LNP.

Later on that day…

So we are a spike proteins now! Hallelujah. We can do so many things! But we have to be careful: there are cells everywhere looking to eat us and turn us into alphabet soup. These so-called antigen-presenting cells just love to gobble up foreign proteins like us and regurgitate our entrails and mount them on Major Histocompatability Complex (MHC) I and II molecules. If they do that, then those T cells and B cells can detect our ground up guts mounted on these complexes and then build an army of cells that can recognize us and kill us! We do not want that. We want to exist. We seem to be doing alright in that desire. We also have to make sure that we don’t end up killing this person we got injected into! That wouldn’t help anyone, now would it. We can embed ourselves into monocytes4 and other cells like epithelial cells5 due to their proclivity to express ACE-26. But there’s a problem here. Through no fault of our own, we are causing some serious micro-clotting issues all over this person’s body by binding all these ACE-2 and CD147 receptors. The inflammatory mediators produced in response to our presence are in overdrive and the entire system is on fire! Hyperinflammation abound! The normal systems that regulate the anti-inflammatory response seem to be on vacation and it just won’t seem to stop. And it’s all because of little old me! Since I was designed to be pretty durable with my extra prolines and my pseudouridines, I am not easily get-riddable. [Word on the street says that my prolines aren’t preventing me from binding ACE-2 at all.] That would explain why so many of me are stuck in monocytes. Teehee. By the way, I forgot to mention, while I was inside the cell as mRNA, there were these TLR-7 molecules that seemed to find me very attractive. They detected some of me and in some cells, caused a chain reaction that obliterated us and the cell.7 TLR-7 is actually really important in the context of COVID-19 clearance.

Perhaps the most successful part of our journeys, however, has been the avoidance of those pesky innate immune mediators in that kid’s nose. Phew, what a bullet we dodged there, right? So we got catapulted all over the body, triggered the T and B cells to respond accordingly with their specificness all along the way, but we avoided all of that other stuff. That’s some weird under-the-radar stuff right there.

Until this body flushes me out (which could take 15 months (see reference #4) unless they inject me again!) I am probably going to cause some systemic problems while I am here. Of these problems includes the dysregulation of the innate immune system, the (subsequent) induction of a hyper-inflamed environment and so many thrombotic events.

I think we can get into the paper now. This article was meant to be about the paper, not an immunology lesson. But it seems these things are simply not mutually exclusive.

So dysregulated inflammation plays an important role in the pathogenesis and severity of COVID-19.9 There are studies that show that long-term innate immune responses can be either increased (trained immunity) or down-regulated (innate immune tolerance) after certain vaccines (such as Bacillus Calmette-Guérin (BCG) and the measles, mumps, and rubella (MMR) vaccines) or infections, so this is not a new thing.10 The way that the authors determined that the innate responses were being modulated in the context of the COVID-19 (the BNT162b2 one) injectables, was by checking out if the levels of certain measurable immune mediators produced in response to TLR stimulation using other virus, bacteria and fungi antigens, were ‘off’. Trained immunity (the one with decreases) is often measured by looking at the rustled-elevated-inflammatory cytokine (like monocyte-derived cytokines TNF-alpha, IL-1beta and IL-1Ra) leaves. When the TLR-3 and TLR-7 receptors were tickled, the amount of TNF-alpha production was way lower (significantly so for TLR-7) following dose 2 of the Pfizer stuff.

TNF-alpha production following stimulation with the TLR7/8 agonist R848 of peripheral blood mononuclear cells from volunteers was significantly decreased after the second [injection].

They also tickled the system with yeast (fungus) and found that the responses (specifically for IL-1beta – a fever-inducing interleukin) were higher following dose 1. The production of the anti-inflammatory cytokine IL-1Ralpha11 (the yin to the IL-1 yang) was reduced in response to a bacterial antigen (lipopolysaccharide (LPS)) and to yeast after the second injection – more evidence that there’s a shift to a stronger inflammatory response to fungal stimuli after injection. They also found that Interleukin-6 (IL-6) responses were similarly decreased, which is interesting, because IL-6 induces the liver to produce c-reactive protein which activates the complement system which helps antibodies out and promotes inflammation which means that doesn’t this mean that we should see less inflammation? So many questions. So very few answers.

Dysregulated continual synthesis of IL-6 plays a pathological effect on chronic inflammation and autoimmunity.

You don’t say.

So that’s what they found in the paper, in a very small nutshell. The figure below shows the design and some of the results of their assays. It basically shows fold-changes in Interferon-gamma (IFN-gamma) (these guys activate macrophages and induce MHC-II molecule expression) and TNF-alpha in response to stimulation of blood cells from injected people using TLR stimulation with various pathogens.

The bottom line here is this. We know that innate responses are vital to a healthy and optimally-functioning immune system. They are vitally integrated with and into the adaptive responses as these two branches work in impeccable, complex harmony. We also know that there are cases where vaccines have caused dysregulation of innate responses in humans. We also know that something is very, very wrong with these COVID-19 injectable products with regards to persistent hyperinflammation and a plethora of systemic and physiologically-comprehensive adverse events including death from micro-emboli formation and clotting. We also know that these authors have now provided evidence to support that these COVID-19 injectable products are modulating innate responses and that this isn’t limited to problems with COVID-19. Problems with fungi, other viruses and bacteria can be anticipated. VAERS has hundreds of thousands of reports of adverse events related to fungal infections, plagues of herpes zoster occurrences (shingles) indicating weakened immunity, cancers coming out of remission, and the list goes on. And most of these reports are made for adults.

Here’s the thing…

Since children have extraordinary capabilities with regards to dealing with COVID-19 via their innate immune system responses, what will happen to them if these are not only by-passed by these injections, but knocked down by them?

Please listen to mighty baby. The kids are alright. Leave them alone. You might not get how this circles back the kids, but it does. Thanks for reading this to the end. And don’t inject kids with this stuff. You might mess them up and they don’t need it.


Source : The Truth Watercooler


Read more at medRxiv

The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses . . . . .