828cloud

Data, Info and News of Life and Economy

Daily Archives: July 26, 2021

In Pictures: Food of Zest by Konishi in Central, Hong Kong

Fine Dining Japanese French Cuisine

The Michelin 1-star Restaurant

Toward One Drug to Treat All Coronaviruses

Safe and effective vaccines offer hope for an end to the COVID-19 pandemic. However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against all coronaviruses as important as ever. Now, researchers reporting in ACS’ Journal of Proteome Research have analyzed viral proteins across 27 coronavirus species and thousands of samples from COVID-19 patients, identifying highly conserved sequences that could make the best drug targets.

Drugs often bind inside “pockets” on proteins that hold the drug snugly, causing it to interfere with the protein’s function. Scientists can identify potential drug-binding pockets from the 3D structures of viral proteins. Over time, however, viruses can mutate their protein pockets so that drugs no longer fit. But some drug-binding pockets are so essential to the protein’s function that they can’t be mutated, and these sequences are generally conserved over time in the same and related viruses.

Matthieu Schapira and colleagues wanted to find the most highly conserved drug-binding pockets in viral proteins from COVID-19 patient samples and from other coronaviruses, revealing the most promising targets for pan-coronavirus drugs.

The team used a computer algorithm to identify drug-binding pockets in the 3D structures of 15 SARS-CoV-2 proteins. The researchers then found corresponding proteins in 27 coronavirus species and compared their sequences in the drug-binding pockets.

The two most conserved druggable sites were a pocket overlapping the RNA binding site of the helicase nsp13, and a binding pocket containing the catalytic site of the RNA-dependent RNA polymerase nsp12. Both of these proteins are involved in viral RNA replication and transcription. The drug-binding pocket on nsp13 was also the most highly conserved across thousands of SARS-CoV-2 samples taken from COVID-19 patients, with not a single mutation.

The researchers say that novel antiviral drugs targeting the catalytic site of nsp12 are currently in phase II and III clinical trials for COVID-19, and that the RNA binding site of nsp13 is a previously underexplored target that should be a high priority for drug development.


Source: American Chemical Society

Chart of the Day: The COVID-19 Delta Wave in Europe

Source : Our World in Data

香港中小學學額空缺較去年增近 8,000

根據教育局最新數字,截止 6 月底,即 20/21 學年仍未結束,學額空缺較去年 10 月中數字大增,其中公營中學增 2,600 個空缺,而公營小學情況更誇張,學額空缺增加 5,300 個。前教育界立法會議員葉建源認為,學額空缺增加,與移民有很大關係,而數字只反映學期完結前情況,不少人趁暑假才離港移民,預期開學後學額空缺會更多。

翻查教育局網站「學校學額空缺情況」,6 月底最新數字公營中學有 42,547 個空缺,公營中學有 12,587 個空缺。

去年 10 月中公營中小學分別約 40,000、7,000 空缺

教育局本月發表《2020/2021學年學生人數統計報告書》比較,當中提及中、小學去年 10 月中學額及學生數字,兩者相減可以得出當時學額空缺的數字。

去年 10 月中,公營中學包括官立、資助中學、按位津貼中學共有 297,610 個學額,而學生有 257,673 個,學額空缺有 39,937 個。而公營小學在去年 10 月中,有 300,521 個學額及 293,323 個學生,當時有 7,198 個學額空缺。

平均每公營中、小學流失約 7 及 12 學生

翻查教育局網站「學校學額空缺情況」,最新數字更新至 6 月底,公營中學有 42,547 個空缺,公營中學有 12,587 個空缺。由去年 10 月中至上月底,8 個月間,公營中學新增 2,610 個學額空缺,佔本學年學生 1.01%、平均每間中學流失近 7 名學生;而公營小學較 8 個月前增 5,389 個學額空缺,平均每間小學流失約 12 名學生。

前教育界立法會議員葉建源認為,學期中學額空缺增加,與移民有很大關係,過去見到不少人舉家、帶同小朋友移民的情況,相關數字亦未見有其他因素影響,如學齡人口、跨境學童等。

葉建源:料開學後學額空缺更多

他指,學期中學額空缺增加,亦反映不少人在學期未完結前就已趕移民。相關數字只統計至 6 月底,他預期很大機會暑假完結、開學初的學額空缺會更多,因為不少人趁暑假才離港移民。

葉建源表示,香港中小學未來情況會更動盪,有機會重現如 10 年前學齡人口下跌致殺校、縮班的情況、教育質素亦會有影響。他認為,政府應及重構思如何調節,例如安排在小學全面貫徹小班教學、調節中學班別人數等。


Source : The Stand News

U.S. New Home Sales Down 6.6% YoY in June, 2021

Source : Trading Economics and Bloomberg

王毅:明确中方对中美关系的三条底线

记者: 潘洁、宋瑞 . . . . . . . . .

  国务委员兼外长王毅26日在天津会见美国常务副国务卿舍曼时,就如何有效管控分歧,防止中美关系失控提出三点要求,明确三条底线:

  第一,美国不得挑战、诋毁甚至试图颠覆中国特色社会主义道路和制度。中国的道路和制度是历史的选择,也是人民的选择,事关14亿中国人民的长远福祉,事关中华民族的前途命运,是中方必须坚守的核心利益。

  第二,美国不得试图阻挠甚至打断中国的发展进程。中国人民当然也有过上更美好生活的权利,中国也有实现现代化的权利,现代化不是美国的专权,这涉及人类的基本良知和国际公义。中方敦促美方尽快取消对华实施的所有单边制裁、高额关税、长臂管辖以及科技封锁。

  第三,美国不得侵犯中国国家主权,更不能破坏中国领土完整。涉疆、涉藏、涉港等问题从来不是什么人权、民主问题,而是反“疆独”、反“藏独”、反“港独”的大是大非问题,任何国家都不会允许国家主权安全受到损害。至于台湾问题,更是重中之重。两岸虽尚未统一,但大陆和台湾同属一个中国、台湾是中国领土一部分这一基本事实从来没有改变,也不会改变。如果“台独”胆敢挑衅,中国有权利采取任何需要的手段予以制止。我们奉劝美方在台湾问题上务必恪守承诺,务必慎重行事。


Source : 新华网


Read also

China puts forward two lists during talks with visiting U.S. deputy secretary of state . . . . .

外交部副部长谢锋与美国常务副国务卿舍曼举行会谈 . . . . .

U.S. Services PMI Dropped in July, 2021

The US Composite index is now running below that of Europe’s

Source : Trading Economics and ZeroHedge